Scientist found out the key to cure type 1 diabetes

Type 1 diabetes cure

A Type 1 diabetes or Juvenile type 1 diabetes mellitus is generally known as  a lifelong chronic disease which cannot be either cured or prevented.

A condition in which a patient depends on daily injections of insulin because the pancreas, a large gland behind the stomach, stops producing insulin, the cells that produce the insulin have been annihilated by the body’s immune system.

What is insulin?

Insulin is a hormone  which is created by the beta cells in the pancreas, anticipated changing sugar, starches and other food into energy that is required for daily life.

 Insulin helps to prevent a harmful rise in the blood glucose level. In type 1 diabetes mellitus, patients ought to take insulin- a hormone created by the beta cells in the pancreas, to keep an unsafe rise in the blood glucose level.

The Type 1 Diabetes Mellitus Cure discovery

The scientist has broken new ground in the search of type 1 diabetes  cure; a researched lead by Indian scientist Dr. Kailash Singh from Uppsala University, their achievement speaks to a major stride forward in using anti-inflammatory immunotherapy to treat type 1 diabetes.

They examined the immune regulatory T-Cells activities in diabetic mouse and discovered their bodies produce damaging proteins rather than defensive anti-inflammatory proteins such as interleukin-35.

To persuade type 1 diabetes in mice, they injected a chemical compound known as streptozotocin. These mice created indications of type 1 diabetes and expanding blood glucose levels comparable as in human type 1 diabetes mellitus.

Interleukin-35(IL-35), injections given after disease actually kept from improvements of type 1 diabetes. Surprisingly, scientist discovered that interleukin-35 injection given to mice, which were diabetic for two consecutive days, were able to normalize their blood sugar concentration.

The result shows that mice engineered to have diabetes that were treated with interleukin-35, a protein made by immune cells had the capacity to keep up an ordinary blood glucose level.

“The good guys have turned bad in early development to type 1 diabetes and in this way our immune cells destroy the beta cell”, said Dr. Kailash Singh.

“To the best of our knowledge, we are the first to demonstrate that Interleukin-35 (IL-35) can reverse established type 1 diabetes,” said Singh.  “Likewise, we are given an insight into a novel mechanism: how immune regulatory T-cells change their destiny under the immune system.”

The discoveries of the new research encourage further research on the use of Interleukin-35 (IL-35) for treating type 1 diabetes mellitus and of few a new piece of information with respect to why immune regulatory T- cells fail in counteracting T1D.

The exploration has been driven by Professor Stellan Sandler, Dr. Kailash Singh and Dr. Lina Thorvaldson in a joint effort with Professor Per-Ola Carlsson and Dr. Daniel Espes at the Department of Medical Cell Biology, Uppsala University, Sweden.

Source:

Uppsala Universitet (Promising progress for new treatment of type 1 diabetes)

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